The R&B singer was forced to apologize and hand his microphone over to the audience because he was unable to complete his song, according to reports.
Eighties pop star Sinitta, who was watching the show, took to her Twitter, writing, “Ne-Yo has had the hiccups for the whole show so far!!”
The Wembley concert is the second of a trio of live shows in the UK, with a final date scheduled tomorrow (Feb. 17) at London HMV Hammersmith Apollo.
Several months ago, Ne-Yo left the stage in tears halfway through a live show in Manchester after complaining of feeling sick.